"Negative building pressure results when an HVAC system inside a building draws in more air from the return ducts than it expels through the supply ducts. A building can be wholly under negative pressure, or exhibit zones of negative pressure in certain areas (e.g. a room contains a return air grille and no supply grille). Given the current configuration of most HVAC systems, most buildings operate under some degree of negative pressure.
Only one fact missing pertaining to the sentence quoted above: "Negative building pressure results when an HVAC system inside a building draws in more air from the return ducts than it expels through the supply ducts". EDIT: Return leaks...if the return ducting is outside the conditioned space, such as an attic or crawl space, return leaks will positively pressurize certain areas of the home. This positive pressure is in respect to outdoors. The end result is the same; infiltration is accelerated in the area under a negative pressure, and the area under positive pressure may be pushing air through wall cavities and penetrations into the ceiling. Under certain conditions that could lead to condensation within the walls (if indoor humidity levels are high enough), and possible mold growth (in addition to compromising insulation R value).
Supply leaks outside the conditioned space can cause one or more interior spaces to go negative.
When buildings operate under negative pressure, some air must be introduced from outside to balance the pressure differential. Ideally, this air would enter the HVAC unit through a valve or duct and be dehumidified before being introduced to the indoor environment. Unfortunately, however, this is rarely the case. HVAC units often have no allowance for outside air, meaning the air must be brought in from different areas. This often results in air being sucked in around doors and windows, through cracks in the foundation, or through other penetrations in the building skin. When this occurs, the introduced air is not dehumidified before entering the indoor environment. Over time, the indoor relative humidity will increase, potentially causing mold growth on cool interior surfaces or inside wall cavities. In addition, negative building pressure can introduce soil gases into the home, including radon.
The dehumidification need is true for cooling season...in heating season the same scenario outlined above can result in low indoor air humidity levels.
To eliminate negative building pressure, the HVAC system must be reconfigured so that any outside air that comes into the home passes over the condenser coils. This process requires careful calculation and precision, so it should only be attempted by a professional."