"R-22 is a bunch of chemicals with a boiler point at 70 degrees..."
For accuracy sake, the boiling point is
40˚ F at 70 psi...
And agreed, the boiling point of the alternatives is similar so at the end of the day, the evaporator will run in the 35˚-40˚ range. If I were to inadvertently "contaminate" a healthy 22 system with an alternative, I might would do the right thing...probably depend on the total system charge.
Virtually all the 22 equipment I deal with, leaks and should have been replaced long ago and doesn't run so hot on 22 so, whether it's 22 or an alternative or a mixture, the true evaporator temp is irrelevant. If the pressure is 65-70 psi and the suction line 50˚-60˚, there
"is some superheat"
and it'll blow cold air.