Sometimes we place too much importance on head pressure. If you guys take some before and after baseline data you'll likely find that when properly charged the blends that run higher head won't increase the current draw of the system over what it was with R-12. In my experience the difference in head pressure with the blends is minimal if you charge the system right. Most of the complaints with the blends in medium temp systems are due to improper charging or a fault with the equipment. I have used several of the R-12 replacement blends and they all worked fairly well in medium temp applications. They have their differences; some run a bit higher head, some have more capacity, some are more compatible with mineral oil, some require greater TXV adjustment...but they all worked. I don't want to get into bashing but HotShot was my least favorite of these. Though it may be one of the easier refrigerants to retrofit, I was not impressed by it's performance in terms of capacity. MP-39 and R-409 get top marks there. MP-39 performs a bit better, but R-409 is more tolerant of mineral oil in remote systems. MP-66 is the clear champ at low temp applications.
As for the hydrocarbon (iso-butane, etc) issue...some of the blends use a small amount of hydrocarbons to improve oil return. Hydrocarbons make an excellent refrigerant and they have great miscibility with conventional oils. Only problem is...they are flammable. Now, the blends sold in the US only have a very small percentage of hydrocarbons. These are typically not enough to be explosive or even flammable without help, but some will burn if subjected to an open flame is memory serves me correctly. Typically, this is not a big deal. However there may be some applications where they could be dangerous.
Back when R-12 was first phased out, there were some blends brought quickly to market (mostly for auto A/C retrofit) that were extremely flammable and even explosive. Hopefully the government put a stop to all of those.